Group A Streptococcus remains viable inside fibrin clots and gains access to human plasminogen for subsequent fibrinolysis and dissemination
H. M. Vu, Z. Liang, Y.-J. Bao, P. G. Carles, J. C. Keane, M. G. Cerney, C. N. Dahnke, A. L. Flores-Mireles, V. A. Ploplis, F. J. Castellino, S. W. Lee
This study shows Group A Streptococcus remains viable inside fibrin clots and accesses plasminogen to dissolve clots and disseminate, with faster dissolution when plasminogen is pre-bound to the bacteria.
bioRxiv · Oct 4, 2023 · PreprintMicrobiology