Author

A. L. Flores-Mireles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 7 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Assay:proteomics· 3 Organism:E. coli· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

J. A. Lemos· 3 shared A. A. La Bella· 2 shared C. Colomer-Winter· 2 shared J. J. Molina· 2 shared M. J. Andersen· 2 shared R. S. Shapiro· 2 shared S. J. Hultgren· 2 shared A. A. LaBella· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersMicrobiology

J. A. Lemos

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Author profile →

8 papers

Recent·Most cited

Group A Streptococcus remains viable inside fibrin clots and gains access to human plasminogen for subsequent fibrinolysis and dissemination

H. M. Vu, Z. Liang, Y.-J. Bao, P. G. Carles, J. C. Keane, M. G. Cerney, C. N. Dahnke, A. L. Flores-Mireles, V. A. Ploplis, F. J. Castellino, S. W. Lee

This study shows Group A Streptococcus remains viable inside fibrin clots and accesses plasminogen to dissolve clots and disseminate, with faster dissolution when plasminogen is pre-bound to the bacteria.

bioRxiv · Oct 4, 2023 · PreprintMicrobiology

Development and applications of a CRISPR activation system for facile genetic overexpression in Candida albicans

N. C. Gervais, A. A. La Bella, L. F. Wensing, J. Sharma, V. Acquaviva, M. Best, R. O. Cadena Lopez, M. Fogal, D. Uthayakumar, A. Chavez, F. Santiago-Tirado, A. L. Flores-Mireles, R. S. Shapiro

This paper develops a CRISPR activation system for genetic overexpression in Candida albicans and demonstrates its ability to drive high-level gene expression and identify novel phenotypes.

bioRxiv · Aug 15, 2022Microbiology

Inhibiting Host Protein Deposition on Urinary Catheters Reduces Urinary Tract Infections

M. J. Andersen, C. Fong, A. A. LaBella, A. J. Molesan, M. M. Champion, C. Howell, A. L. Flores-Mireles

The paper shows inhibiting host protein deposition on urinary catheters reduces microbial colonization and urinary tract infections.

bioRxiv · Dec 7, 2021Microbiology

The AdcACB/AdcAII system is Essential for Zinc Homeostasis and an Important Contributor of Enterococcus faecalis Virulence

J. A. Lemos, L. Lam, D. Brunson, A. L. Flores-Mireles, J. J. Molina

bioRxiv · Dec 1, 2021Microbiology

The catheterized bladder environment promotes Efg1- and Als1-dependent Candida albicans infection

A. A. La Bella, M. J. Andersen, N. Gervais, J. J. Molina, A. Molesan, P. V. Stuckey, L. Wensing, C. J. Nobile, R. S. Shapiro, F. H. Santiago-Tirado, A. L. Flores-Mireles

This study identifies Efg1- and Als1-dependent mechanisms by which Candida albicans forms biofilms and causes infection in the catheterized bladder environment.

bioRxiv · Jun 1, 2021Microbiology

(p)ppGpp and CodY promote Enterococcus faecalis virulence in a murine model of catheter-associated urinary tract infection

C. Colomer-Winter, A. L. Flores-Mireles, S. Kundra, S. J. Hultgren, J. A. Lemos

This study shows that (p)ppGpp and CodY enhance Enterococcus faecalis virulence in a mouse model of catheter-associated urinary tract infection by maintaining metabolic balance during infection.

bioRxiv · May 31, 2019Microbiology

The commercial antimicrobial triclosan induces high levels of antibiotic tolerance in vitro and reduces antibiotic efficacy up to 100-fold in vivo

C. S. Westfall, A. L. Flores-Mireles, J. I. Robinson, A. J. L. Lynch, S. Hultgren, J. P. Henderson, P. A. Levin

This paper shows triclosan increases antibiotic tolerance in bacteria and reduces antibiotic efficacy in mice.

bioRxiv · Dec 5, 2018 · PreprintMicrobiology

Manganese acquisition is essential for virulence of Enterococcus faecalis

C. Colomer-Winter, A. L. Flores-Mireles, S. P. Baker, K. L. Frank, A. J. Lynch, S. J. Hultgren, T. Kitten, J. A. Lemos

This study identifies and characterizes Mn acquisition systems in E. faecalis, showing their critical role in virulence and demonstrating their potential as antimicrobial targets.

bioRxiv · May 16, 2018Microbiology