F. J. Castellino

This study shows Group A Streptococcus remains viable inside fibrin clots and accesses plasminogen to dissolve clots and disseminate, with faster dissolution when plasminogen is pre-bound to the bacteria.

This paper presents a high-resolution cryo-EM structure of a bacterial M-protein, showing it is a monomeric globular structure, not a dimeric coiled-coil as previously believed.

This study presents a high-resolution cryo-EM structure of Streptococcus pyogenes enolase, revealing its octameric conformation and insights into its function as a plasminogen receptor.

This study shows that the Thr4 residue in the SrtA cleavage site of Streptococcus pyogenes M-protein evolved to ensure efficient SrtA cleavage over non-functional cleavage by LPXTGase, stabilizing the virulence factor on the cell wall.

This study shows fibrin regulates neutrophil effector functions at mucosal barriers, linking impaired fibrinolysis to oral mucosal disease.

The paper identifies a Streptolysin S-like toxin biosynthetic cluster in a highly pathogenic MRSA strain and investigates its potential role through genetic and phenotypic assays.