Author

S. W. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

F. J. Castellino· 3 shared D. E. Hammers· 2 shared F. R. Fields· 2 shared H. M. Vu· 2 shared J. N. Ross· 2 shared K. E. Carothers· 2 shared V. A. Ploplis· 2 shared Z. Liang· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersMicrobiology

F. J. Castellino

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Group A Streptococcus remains viable inside fibrin clots and gains access to human plasminogen for subsequent fibrinolysis and dissemination

H. M. Vu, Z. Liang, Y.-J. Bao, P. G. Carles, J. C. Keane, M. G. Cerney, C. N. Dahnke, A. L. Flores-Mireles, V. A. Ploplis, F. J. Castellino, S. W. Lee

This study shows Group A Streptococcus remains viable inside fibrin clots and accesses plasminogen to dissolve clots and disseminate, with faster dissolution when plasminogen is pre-bound to the bacteria.

bioRxiv · Oct 4, 2023 · PreprintMicrobiology

Evolution of Gram+ Streptococcus pyogenes has maximized efficiency of the Sortase A cleavage site

B. M. Readnour, Y. A. Ayinuola, B. Russo, Z. Liang, V. A. Fischetti, V. Ploplis, S. W. Lee, F. J. Castellino

This study shows that the Thr4 residue in the SrtA cleavage site of Streptococcus pyogenes M-protein evolved to ensure efficient SrtA cleavage over non-functional cleavage by LPXTGase, stabilizing the virulence factor on the cell wall.

bioRxiv · Dec 21, 2021 · PreprintMicrobiology

E prostanoid receptor 4 expressing macrophages promote the regeneration of the intestinal epithelial barrier upon inflammation

Y. R. Na, D. Jung, M. Stakenborg, G. J. Gu, M. R. Jeong, H. R. Jang, S. Y. Suh, H. J. Kim, Y. H. Kwon, T. S. Sung, S. B. Ryoo, K. J. Park, J. P. Im, J. Y. Park, Y. S. Lee, , S. H. Seok

The paper identifies EP4-expressing intestinal macrophages that promote mucosal healing by secreting CXCL1 during inflammation resolution.

bioRxiv · May 4, 2020Immunology

Discovery of genes encoding a Streptolysin S-like toxin biosynthetic cluster in a select highly pathogenic methicillin resistant Staphylococcus aureus JKD6159 strain

T. Kane, K. E. Carothers, Y. Bao, W.-S. Yeo, T. Bae, C. Park, F. R. Fields, H. M. Vu, D. E. Hammers, J. N. Ross, V. A. Ploplis, F. J. Castellino, S. W. Lee

The paper identifies a Streptolysin S-like toxin biosynthetic cluster in a highly pathogenic MRSA strain and investigates its potential role through genetic and phenotypic assays.

bioRxiv · Aug 31, 2019 · PreprintMicrobiology

Clustering and rapid long-range motility behavior of bacteria by type IV pili

C. S. Madukoma, N. Morales-Soto, A. E. Mattingly, S. W. Lee, J. D. Shrout

The paper studies how Pseudomonas aeruginosa uses type IV pili for rapid, long-range motility and clustering behavior without exogenous DNA or polysaccharides.

bioRxiv · Jan 21, 2019 · PreprintMicrobiology

The tumor suppressor p53 promotes carcinoma invasion and collective cellular migration

S. HE, C. V. Carman, J. H. Lee, B. Lan, S. Koehler, L. Atia, C. Y. Park, J. H. Kim, J. A. Mitchel, J.-A. Park, J. P. Butler, S. W. Lee, J. Fredberg

This study shows that p53 loss decreases single-cell motility and invasion in 2-D and 3-D assays, but promotes collective cellular migration in spheroids.

bioRxiv · Jul 30, 2018Cancer Biology

Novel antimicrobial peptide discovery using machine learning and biophysical selection of minimal bacteriocin domains

F. R. Fields, S. D. Freed, K. E. Carothers, M. N. Hamid, D. E. Hammers, J. N. Ross, V. R. Kalwajtys, A. J. Gonzalez, A. D. Hildreth, I. Friedberg, S. W. Lee

This study develops a pipeline combining machine learning and biophysical filters to design and test minimal bacteriocin peptides for antimicrobial activity.

bioRxiv · May 4, 2018Microbiology