H. Mehta

Experimental evolution of Pseudomonas aeruginosa to colistin in spatially confined microdroplets identifies evolutionary trajectories consistent with adaptation in microaerobic lung environments

This study uses microdroplet emulsions to simulate CF lung microenvironments and identifies evolutionary trajectories of Pseudomonas aeruginosa to colistin resistance, showing that PhoP/PhoQ pathway mutations are favored in microaerobic conditions.

TFAM-dependent mitochondrial integrity in regulatory T cells preserves immune landscape and restrains inflammaging

This study identifies TFAM-dependent mitochondrial integrity in Tregs as critical for preserving immune homeostasis and preventing inflammaging.