S. Seo

Host-encoded DNA methyltransferases modify the epigenome and host tropism of invading phages

The paper shows adapted phages share methylated motifs with their most recent host, indicating epigenetic changes influence host tropism.

Allelic bias contributes to heterogeneous phenotypes of NK cell deficiency

This study shows that allelic bias in GINS4 variants contributes to variable clinical and cellular phenotypes in NK cell deficiency.

Replication stress in activated human NK cells induces sensitivity to apoptosis

This study shows that replication stress in activated human NK cells increases apoptosis and impairs function, linking helicase deficiency to NK cell deficiency.

Experimental evolution of Pseudomonas aeruginosa to colistin in spatially confined microdroplets identifies evolutionary trajectories consistent with adaptation in microaerobic lung environments

This study uses microdroplet emulsions to simulate CF lung microenvironments and identifies evolutionary trajectories of Pseudomonas aeruginosa to colistin resistance, showing that PhoP/PhoQ pathway mutations are favored in microaerobic conditions.

Methyl Halide Transferase-Based Gas Reporters for Quantification of Filamentous Bacteria in Microdroplet Emulsions

This paper introduces a methyl halide transferase-based gas reporter system to quantify filamentous bacteria in microdroplet emulsions, achieving higher sensitivity than optical methods.

The SPICA Coarse-Grained Force Field for Proteins and Peptides

The paper develops and improves a coarse-grained force field for proteins and peptides, showing good performance in simulating membrane protein behavior and interactions.

Differential integrin adhesome expression defines human natural killer cell residency and developmental stage

This study identifies differences in integrin adhesome expression in human NK cells based on tissue location and developmental stage, linking these differences to cortical actin homeostasis.

CEP290 myosin-tail homology domain is essential for protein confinement between inner and outer segments in photoreceptors

This study shows that the myosin-tail homology domain of CEP290 is essential for protein confinement between inner and outer segments in photoreceptors, with specific effects on RHO mislocalization and retinal degeneration.

Arginine culture generates triacylglycerol by triggering nitrogen starvation responses during robust growth in Chlamydomonas

The paper shows that arginine culture induces nitrogen starvation responses in microalgae without limiting growth or photosynthesis, leading to increased lipid droplet accumulation.