MicrobiologybioRxivPreprint
Experimental evolution of Pseudomonas aeruginosa to colistin in spatially confined microdroplets identifies evolutionary trajectories consistent with adaptation in microaerobic lung environments
H. S. Disney-McKeethen, S. Seo, H. Mehta…·Y. Shamoo
This study uses microdroplet emulsions to simulate CF lung microenvironments and identifies evolutionary trajectories of Pseudomonas aeruginosa to colistin resistance, showing that PhoP/PhoQ pathway mutations are favored in microaerobic conditions.
DOI 10.1101/2023.06.12.544597