The polyol pathway is an evolutionarily conserved system for sensing glucose uptake
H. Sano, A. Nakamura, M. Yamane, H. Niwa, T. Nishimura, K. Araki, K. Takemoto, K.-i. Ishiguro, H. Aoki, M. Kojima
The paper shows the polyol pathway senses glucose uptake in flies and mice, enabling metabolic remodeling through ChREBP/MondoA activation.
bioRxiv · Sep 14, 2021Physiology