Naturally mutated spike proteins of SARS-CoV-2 variants show differential levels of cell entry
S. Ozono, Y. Zhang, H. Ode, T. S. Tan, K. Imai, K. Miyoshi, S. Kishigami, T. Ueno, Y. Iwatani, T. Suzuki, K. Tokunaga
The paper examines how naturally occurring mutations in SARS-CoV-2 spike proteins affect cell entry via ACE2 and TMPRSS2, finding that the D614G mutation increases infectivity but remains neutralization-sensitive.
Nature Communications · Feb 8, 2021Peer-reviewedMicrobiology