Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
10 papers
Recent·Most cited
W. Takagi, A. Masuda, K. Shimoyama, K. Tokunaga, S. Hyodo, Y. Sato-Takabe
This study investigates the microbial environment inside the egg capsules of cloudy catsharks during oviposition, finding low bacterial density and unique microbial composition that may protect embryos from infection.
bioRxiv · Feb 28, 2024Microbiology
M. M. Begum, K. Ichihara, O. Takahashi, H. Nasser, M. Jonathan, K. Tokunaga, I. Yoshida, M. Nagashima, K. Sadamasu, K. Yoshimura, K. Sato, T. Ikeda
This study examines virological parameters of SARS-CoV-2 variants correlating with spike protein fusogenicity, finding strong links with S1/S2 cleavage efficiency and plaque size.
bioRxiv · Oct 3, 2023Microbiology
S. Fujita, Y. Kosugi, I. Kimura, K. Tokunaga, The Genotype to Phenotype Japan (G2P-Japan) Consortium, J. Ito, K. Sato
The paper identifies specific residues in the spike protein and ACE2 receptor that determine the host tropism of two SARS-CoV-2-related bat coronaviruses.
bioRxiv · Apr 13, 2023 · PreprintMicrobiology
H. Tatetsu, M. Watanabe, J. Liu, K. Tokunaga, E. Iwanaga, Y. Komohara, E. Thrash, M. Matsuoka, D. G. Tenen, L. Chai
This study identifies the cellular origin of aberrant SALL4 expression in MDS using mass cytometry, showing it is mainly in HSPC and myeloid lineages, with SALL4/p53 co-expression linked to TP53 mutations.
bioRxiv · Dec 5, 2022Cell Biology
I. Kimura, Y. Kosugi, J. Wu, D. Yamasoba, E. P. Butlertanaka, Y. L. Tanaka, Y. Liu, K. Shirakawa, Y. Kazuma, R. Nomura, Y. Horisawa, K. Tokunaga, A. Takaori-Kondo, H. Arase, The Genotype to Phenotype Japan (G2P-Japan) Consortium, , K. Sato
The paper investigates the SARS-CoV-2 Lambda variant, finding it more infectious due to specific mutations and better immune evasion, contributing to its spread in South America.
bioRxiv · Jul 28, 2021Microbiology
A. Saito, T. Irie, R. Suzuki, T. Maemura, H. Nasser, K. Uriu, Y. Kosugi, K. Shirakawa, K. Sadamasu, I. Kimura, J. Ito, J. Wu, K. Iwatsuki-Horimoto, M. Ito, S. Yamayoshi, , K. Sato
This study shows the P681R mutation in the SARS-CoV-2 spike protein enhances fusogenicity and pathogenicity in the Delta variant compared to the prototypic virus.
bioRxiv · Jun 17, 2021Microbiology
Y. Zhang, S. Ozono, T. Tada, M. Tobiume, M. Kameoka, S. Kishigami, H. Fujita, K. Tokunaga
This study identifies MARCH8 as an antiviral factor that ubiquitinates and degrades viral envelope glycoproteins by targeting their cytoplasmic lysine residues.
bioRxiv · Apr 20, 2021Microbiology
S. Ozono, Y. Zhang, H. Ode, T. S. Tan, K. Imai, K. Miyoshi, S. Kishigami, T. Ueno, Y. Iwatani, T. Suzuki, K. Tokunaga
The paper examines how naturally occurring mutations in SARS-CoV-2 spike proteins affect cell entry via ACE2 and TMPRSS2, finding that the D614G mutation increases infectivity but remains neutralization-sensitive.
Nature Communications · Feb 8, 2021Peer-reviewedMicrobiology
S. Ozono, Y. Zhang, M. Tobiume, S. Kishigami, K. Tokunaga
This paper introduces a HiBiT-based luciferase assay for rapid and accurate quantification of HIV-1 production, outperforming traditional methods like ELISA.
bioRxiv · Apr 10, 2020Microbiology
Y. Zhang, T. Tada, S. Ozono, S. Kishigami, H. Fujita, K. Tokunaga
This study identifies two distinct mechanisms by which MARCH8 inhibits viral infection: ubiquitination of VSV-G and tyrosine motif-dependent sorting of HIV-1 Env.
bioRxiv · Apr 9, 2020Microbiology