Clonal spreading of tumor-infiltrating T cells underlies the robust antitumor immune responses
H. Aoki, M. Tsunoda, H. Ogiwara, H. Shimizu, H. Abe, T. Abe, S. Shichino, K. Matsushima, S. Ueha
This study shows that polyclonal expansion of tumor-reactive T cells, not oligoclonal expansion, correlates with antitumor effects in response to anti-PD-L1 and anti-CD4 treatments.
bioRxiv · Apr 19, 2022Immunology