H. Shimizu

Extensive distribution of β-1,2-glucanases: finding of new glycoside hydrolase families of β-1,2-glucanases

The paper identifies three new glycoside hydrolase families of β-1,2-glucanases and reveals their functional and structural relationships within a superfamily.

Clonal spreading of tumor-infiltrating T cells underlies the robust antitumor immune responses

This study shows that polyclonal expansion of tumor-reactive T cells, not oligoclonal expansion, correlates with antitumor effects in response to anti-PD-L1 and anti-CD4 treatments.

Two doses of mRNA vaccine elicit cross-neutralizing memory B-cells against SARS-CoV-2 Omicron variant

The paper shows that two doses of mRNA vaccine generate cross-neutralizing memory B-cells against SARS-CoV-2 Omicron variant, which are retained and contribute to enhanced antibody responses after a third dose.

Metabolic flux and flux balance analyses indicate the relevance of metabolic thermogenesis and aerobic glycolysis in cancer cells

The paper uses metabolic flux analysis to show that cancer cells prefer aerobic glycolysis over oxidative phosphorylation due to reduced metabolic heat generation.

T cell receptor (TCR) repertoire analysis reveals a highly conserved TCR repertoire in a bilateral tumor mouse model

This study shows that the TCR repertoire is highly conserved between bilateral tumors in a mouse model, supporting its use for temporal analysis of antitumor T cell responses.

The peripheral T cell population is associated with pneumonia severity in cynomolgus monkeys experimentally infected with severe acute respiratory syndrome coronavirus 2

This study shows that cynomolgus monkeys with lower peripheral T cell counts experience more severe pneumonia after SARS-CoV-2 infection compared to those with higher T cell counts.

Hair follicle stem cell progeny heal blisters while pausing skin development

The paper shows that skin blisters heal by sacrificing developmental programs, with HF stem cell progeny repairing wounds without promoting hair follicle growth.

Origination of the circadian clock system in stem cells regulates cell differentiation in Arabidopsis thaliana.

The paper shows that the circadian clock in Arabidopsis stem cells regulates cell differentiation through BES1-mediated repression of LHY.

The Calcineurin-FoxO-MuRF1 Signaling Pathway Regulates Myofibril Integrity in Cardiomyocytes

This study identifies a Calcineurin-FoxO-MuRF1 signaling pathway that mediates Ca2+ overload-induced myofibril degradation in cardiomyocytes using zebrafish models.