Author

H. Pakula

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

M. Loda· 2 shared B. D. Robinson· 1 shared B. Piyarathna· 1 shared C. Abate-Shen· 1 shared C. Coarfa· 1 shared C. E. Barbieri· 1 shared C. F. Ribeiro· 1 shared C. Fidalgo-Ribeiro· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

M. Loda

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Interplay of IGF1R and estrogen signaling regulates hematopoietic stem and progenitor cells

Y. Xie, D. Xiang, X. Hu, H. Pakula, E.-S. Park, J. Chi, D. E. Linn, L. Tao, Z. Li

This study shows that IGF1R and estrogen signaling interact to regulate HSPC proliferation, with sex-specific effects observed in adult and fetal hematopoiesis.

bioRxiv · Mar 20, 2024 · PreprintCell Biology

Distinct mesenchymal cell states mediate prostate cancer progression

H. Pakula, M. Omar, R. Carelli, F. Pederzoli, G. N. Fanelli, T. Pannellini, L. Van Emmenis, S. Rodrigues, C. Fidalgo-Ribeiro, P. V. Nuzzo, N. J. Brady, M. Jere, C. Unkenholz, M. K. Alexanderani, F. Khani, , M. Loda

This study identifies distinct mesenchymal cell states in prostate cancer stroma that correlate with metastatic progression and develops a gene signature to predict patient outcomes.

bioRxiv · Mar 29, 2023Cancer Biology

Adipose triglyceride lipase is regulated by CAMKK2-AMPK signaling and drives advanced prostate cancer

D. Awad, T. L. Pulliam, M. L. Spradlin, P. H.-A. Cao, E. Subramani, T. V. Tellman, C. F. Ribeiro, H. Pakula, J. J. Ackroyd, M. M. Murray, J. J. Han, B. Piyarathna, J. M. Drake, M. M. Ittmann, C. Coarfa, , D. E. Frigo

This study identifies ATGL as a CAMKK2-AMPK target that promotes CRPC progression by enhancing lipase activity and metabolic plasticity, suggesting it as a therapeutic target.

bioRxiv · Nov 2, 2022 · PreprintCancer Biology