Author

T. Pannellini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2

Frequent Co-Authors

B. D. Robinson· 2 shared C. Abate-Shen· 2 shared M. Loda· 2 shared A. B. Pernis· 1 shared A. Califano· 1 shared A. M. Rosenfeld· 1 shared A. Trivedi· 1 shared A. Vasciaveo· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCancer Biology

B. D. Robinson

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Lymphatic Dysfunction Models an Autoimmune Emphysema Phenotype of Chronic Obstructive Pulmonary Disease

B. Summers, K. Kim, T. M. Lu, S. Houghton, J. R. Quintero, J. Cala-Garcia, T. Pannellini, F. Polverino, R. Lis, A. Trivedi, H. O. Reed

This study shows that lymphatic dysfunction drives lung injury and autoimmune emphysema in COPD by promoting TLO formation and autoantibody production in mice, with similar patterns observed in human COPD patients.

bioRxiv · Oct 31, 2023 · PreprintPathology

NSD2 maintains lineage plasticity and castration-resistance in neuroendocrine prostate cancer

J. J. Li, A. Vasciaveo, D. Karagiannis, Z. Sun, X. Chen, F. Socciarelli, Z. Frankenstein, M. Zou, T. Pannellini, Y. Chen, K. Gardner, B. D. Robinson, J. de Bono, C. Abate-Shen, M. A. Rubin, , M. M. Shen

This study identifies NSD2 as a key driver of lineage plasticity and castration-resistance in neuroendocrine prostate cancer, showing its inhibition can restore sensitivity to AR inhibitors.

bioRxiv · Jul 18, 2023 · PreprintCancer Biology

Distinct mesenchymal cell states mediate prostate cancer progression

H. Pakula, M. Omar, R. Carelli, F. Pederzoli, G. N. Fanelli, T. Pannellini, L. Van Emmenis, S. Rodrigues, C. Fidalgo-Ribeiro, P. V. Nuzzo, N. J. Brady, M. Jere, C. Unkenholz, M. K. Alexanderani, F. Khani, , M. Loda

This study identifies distinct mesenchymal cell states in prostate cancer stroma that correlate with metastatic progression and develops a gene signature to predict patient outcomes.

bioRxiv · Mar 29, 2023Cancer Biology

Sex-specific differences in the function and differentiation of ABCsmark TLR7-driven immunopathogenesis

E. Ricker, M. Manni, D. Flores-Castro, D. Jenkins, S. Gupta, J. Rivera-Correa, W. Meng, A. M. Rosenfeld, T. Pannellini, M. Bachu, Y. Chinenov, P. K. Sculco, R. Jessberger, E. T. Luning Prak, A. B. Pernis

The paper shows sex-specific differences in ABCs expansion, ISG signature upregulation, and differentiation in TLR7-driven immunopathogenesis, with Tlr7 duplication in males exacerbating disease severity.

bioRxiv · Jan 20, 2021 · PreprintImmunology