Author

H. R. Flynn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Organism:human· 1 Organism:mouse· 1 Organism:plant (other)· 1

Frequent Co-Authors

C. Withers-Martinez· 2 shared D. A. Baker· 2 shared K. Koussis· 2 shared M. J. Blackman· 2 shared A. C. Balestra· 1 shared A. Hainard· 1 shared A. J. Perrin· 1 shared A. P. Snijders· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersMicrobiology

C. Withers-Martinez

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Activation loop phosphorylation and cGMP saturation of PKG regulate egress of malaria parasites.

K. Koussis, S. Haase, C. Withers-Martinez, H. R. Flynn, S. Kunzelmann, E. Christodoulou, F. Ibrahim, M. Skehel, D. A. Baker, M. J. Blackman

This study shows that PKG regulation in malaria parasites involves cGMP saturation and activation loop phosphorylation, with phosphorylation being essential for in vivo function.

bioRxiv · Feb 4, 2024Microbiology

A multipass membrane protein interacts with the cGMP-dependent protein kinase to regulate critical calcium signals in malaria parasites

A. C. Balestra, K. Koussis, N. Klages, S. A. Howell, H. R. Flynn, M. Bantscheff, C. Pasquarello, A. J. Perrin, L. Brusini, P. Arboit, O. Sanz, L. Peces-Barba Castano, C. Withers-Martinez, A. Hainard, S. Ghidelli-Disse, , M. Brochet

This study identifies ICM1, a multipass membrane protein interacting with PKG in malaria parasites, and shows it regulates calcium signals critical for gametogenesis and parasite survival.

bioRxiv · Jul 18, 2020Microbiology