Author

C. Withers-Martinez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

D. A. Baker· 2 shared H. R. Flynn· 2 shared K. Koussis· 2 shared M. J. Blackman· 2 shared A. C. Balestra· 1 shared A. Hainard· 1 shared A. J. Perrin· 1 shared A. P. Snijders· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMicrobiology

D. A. Baker

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Activation loop phosphorylation and cGMP saturation of PKG regulate egress of malaria parasites.

K. Koussis, S. Haase, C. Withers-Martinez, H. R. Flynn, S. Kunzelmann, E. Christodoulou, F. Ibrahim, M. Skehel, D. A. Baker, M. J. Blackman

This study shows that PKG regulation in malaria parasites involves cGMP saturation and activation loop phosphorylation, with phosphorylation being essential for in vivo function.

bioRxiv · Feb 4, 2024Microbiology

A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite

A. Ramaprasad, P.-C. Burda, E. Calvani, A. Sait, S. A. Palma-Duran, C. Withers-Martinez, F. Hackett, J. I. MacRae, L. Collinson, T. Gilberger, M. Blackman

This study identifies PfGDPD as a choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in Plasmodium falciparum.

bioRxiv · Jun 14, 2022Microbiology

A multipass membrane protein interacts with the cGMP-dependent protein kinase to regulate critical calcium signals in malaria parasites

A. C. Balestra, K. Koussis, N. Klages, S. A. Howell, H. R. Flynn, M. Bantscheff, C. Pasquarello, A. J. Perrin, L. Brusini, P. Arboit, O. Sanz, L. Peces-Barba Castano, C. Withers-Martinez, A. Hainard, S. Ghidelli-Disse, , M. Brochet

This study identifies ICM1, a multipass membrane protein interacting with PKG in malaria parasites, and shows it regulates calcium signals critical for gametogenesis and parasite survival.

bioRxiv · Jul 18, 2020Microbiology