Author

S. A. Howell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:plant (other)· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. P. Snijders· 3 shared M. J. Blackman· 3 shared K. Koussis· 2 shared A. C. Balestra· 1 shared A. Hainard· 1 shared A. J. Perrin· 1 shared A. P. Patel· 1 shared A. Ramaprasad· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersMicrobiology

A. P. Snijders

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Author profile →

4 papers

Recent·Most cited

A malaria parasite phospholipase facilitates efficient asexual blood stage egress

A. Ramaprasad, P.-C. Burda, K. Koussis, J. A. Thomas, E. Pietsch, E. Calvani, S. A. Howell, J. I. MacRae, A. P. Snijders, T. W. Gilberger, M. J. Blackman

This study identifies LCAT as a key enzyme required for efficient egress of malaria parasites from red blood cells during the asexual blood stage.

bioRxiv · Mar 13, 2023Microbiology

The Aspartyl Protease Ddi1 Is Essential for Erythrocyte Invasion by the Malaria Parasite

S. Ridewood, B. Dirac-Svejstrup, S. A. Howell, A. Weston, C. Lehmann, A. P. Patel, L. Collinson, R. Bingham, D. Powell, A. Snijder, J. Q. Svejstrup, E. Deu

This study shows that PfDdi1 proteolytic activity is essential for Plasmodium falciparum erythrocyte invasion and identifies it as a potential antimalarial target.

bioRxiv · May 11, 2021 · PreprintCell Biology

A multipass membrane protein interacts with the cGMP-dependent protein kinase to regulate critical calcium signals in malaria parasites

A. C. Balestra, K. Koussis, N. Klages, S. A. Howell, H. R. Flynn, M. Bantscheff, C. Pasquarello, A. J. Perrin, L. Brusini, P. Arboit, O. Sanz, L. Peces-Barba Castano, C. Withers-Martinez, A. Hainard, S. Ghidelli-Disse, , M. Brochet

This study identifies ICM1, a multipass membrane protein interacting with PKG in malaria parasites, and shows it regulates calcium signals critical for gametogenesis and parasite survival.

bioRxiv · Jul 18, 2020Microbiology

The malaria parasite sheddase SUB2 governs host red blood cell membrane sealing at invasion

C. R. Collins, F. Hackett, S. A. Howell, A. P. Snijders, M. R. Russell, L. M. Collinson, M. J. Blackman

This study shows that the malaria parasite's SUB2 protease is essential for shedding surface proteins during RBC invasion and for sealing the host cell membrane.

bioRxiv · Jul 15, 2020Microbiology