S. Haase

Activation loop phosphorylation and cGMP saturation of PKG regulate egress of malaria parasites.

This study shows that PKG regulation in malaria parasites involves cGMP saturation and activation loop phosphorylation, with phosphorylation being essential for in vivo function.

H3.3-G34R Mutation-Mediated Epigenetic Reprogramming Leads to Enhanced Efficacy of Immune Stimulatory Gene Therapy in Diffuse Hemispheric Gliomas

This study shows that H3.3-G34R mutations reprogram the tumor immune microenvironment in diffuse hemispheric gliomas, enhancing the efficacy of immune stimulatory gene therapy and leading to long-term survival in treated mice.

Zinc Finger MYND-Type Containing 8 (ZMYND8) is epigenetically regulated in mutant Isocitrate Dehydrogenase 1 (IDH1) glioma to promote radioresistance

This paper identifies ZMYND8 as a gene epigenetically regulated by mIDH1 that promotes radioresistance in glioma cells, and shows its knockdown enhances radiosensitivity.

Plasmodium falciparum protein Pfs16 is a target for transmission-blocking antimalarial drug development

This study identifies Pfs16 as the cellular target of the N-4HCS compound DDD01035881, which blocks Plasmodium male gamete formation.

Actomyosin forces and the energetics of red blood cell invasion by the malaria parasite Plasmodium falciparum

This study investigates the role of actomyosin motors in Plasmodium falciparum invasion of red blood cells, identifying three energetic barriers and distinct myosin functions.

G-CSF SECRETED BY EPIGENETICALLY REPROGRAMMED MUTANT IDH1 GLIOMA STEM CELLS REVERSES THE MYELOID CELLS'-MEDIATED IMMUNOSUPPRESSIVE TUMOR MICROENVIRONMENT

The paper shows that mIDH1 glioma stem cells secrete G-CSF, which reprograms myeloid cells to become non-immunosuppressive, altering the tumor microenvironment.

Structure of Full Length Plasmodium Myosin A and its light chain PfELC, dual targets against malaria parasite pathogenesis

The paper presents the full-length structure of Plasmodium falciparum Myosin A (PfMyoA) and its light chain PfELC, revealing interactions critical for motor function and identifying PfELC as a potential antimalarial target.

Identification and characterisation of a phospholipid scramblase in the malaria parasite Plasmodium falciparum

The paper identifies and characterizes a phospholipid scramblase in Plasmodium falciparum, showing its activity and expression but not essentiality for erythrocyte invasion.

Inference of Gene Regulatory Network Uncovers the Linkage Between Circadian Clock and Crassulacean Acid Metabolism in Kalanchoë fedtschenkoi

The paper infers a gene regulatory network in Kalanchoë fedtschenkoi to explore the link between circadian clock and CAM metabolism, revealing regulatory connections and potential applications for crop engineering.