E. Christodoulou

Evolution and inhibition of the FIKK effector kinase family in P. falciparum

This study investigates the evolution and inhibition of FIKK kinases in P. falciparum, showing they can be inhibited by a single compound.

Activation loop phosphorylation and cGMP saturation of PKG regulate egress of malaria parasites.

This study shows that PKG regulation in malaria parasites involves cGMP saturation and activation loop phosphorylation, with phosphorylation being essential for in vivo function.

Wnt/β-catenin signaling improves oxidative metabolism in skeletal muscle of obese ob/ob mice

This study shows that activating Wnt/β-catenin signaling in skeletal muscle of obese mice improves oxidative metabolism and reduces hyperglycemia.

Primary cilia loss promotes reactivation of morphogenesis and cyst-fission through a deregulated TGFβ-ECM-Integrin axis in polycystic liver disease.

The paper shows that loss of primary cilia in adult mouse bile duct cells leads to cyst formation via a fibronectin-rich microenvironment and a novel cyst-fission process, which can be inhibited by targeting a specific integrin receptor.

Protein ubiquitylation is essential for the schizont to merozoite transition in Plasmodium falciparum blood-stage development

This paper identifies ubiquitylation sites in Plasmodium falciparum and shows that ubiquitylation is essential for the schizont to merozoite transition.