Author

H. R. Smith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Approach:deep learning· 1 Assay:electronic health records· 1 Approach:experimental assay· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

A. Boufersaoui· 1 shared A. Clark· 1 shared A. H. Shilleh· 1 shared A. Machireddy· 1 shared A. P. Davies· 1 shared B. Marzullo· 1 shared C. Bonner· 1 shared C. D. Ceresa· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperPhysiology

A. Boufersaoui

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

High-resolution glucose tracing and in situ imaging reveals regulated lactate production in human pancreatic β cells

F. Cuozzo, K. Viloria, A. H. Shilleh, D. Nasteska, C. Frazer-Morris, Z. Jiao, A. Boufersaoui, B. Marzullo, H. R. Smith, C. Bonner, J. Kerr-Conte, F. Pattou, R. Nano, L. Piemonti, P. R. Johnson, , D. J. Hodson

The paper uses metabolic tracing and imaging to show that human pancreatic β cells produce lactate, regulated by LDHB expression, which affects Ca2+ spiking without altering ATP/ADP levels.

bioRxiv · Dec 21, 2022 · PreprintPhysiology

Robust Segmentation of Cellular Ultrastructure on Sparsely Labeled 3D Electron Microscopy Images using Deep Learning

A. Machireddy, G. Thibault, K. G. Loftis, K. Stoltz, C. E. Bueno, H. R. Smith, J. L. Riesterer, J. W. Gray, X. Song

This paper develops a deep learning method to segment cellular ultrastructures in 3D EM images, achieving high accuracy for nuclei and nucleoli in cancer biopsies.

bioRxiv · May 27, 2021Cancer Biology