Author
R. Fujisawa
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
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2018-2024 · peak 4/yrCo-Author Collaboration Network
10 top collaborators · 45 mutual co-author links9 papers
Recent·Most cited
DONSON is required for CMG helicase assembly in the mammalian cell cycle
K. Labib, C. Evrin, V. Alvarez, J. Ainsworth, R. Fujisawa, C. Alabert
This study identifies DONSON as essential for CDC45-MCM-GINS helicase assembly during S-phase, linking it to Meier-Gorlin Syndrome.
bioRxiv · Aug 16, 2023Biochemistry
Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of nsp5 Main Protease
C. Basier, R. Beale, G. Bineva-Todd, B. Canal, J. F. Curran, T. D. Deegan, J. F. Diffley, R. Fujisawa, M. Howell, D. Joshi, K. Labib, C. T. Lim, J. Milligan, H. Nagaraj, N. O'Reilly, , T. U. Zeisner
This study identifies small molecule inhibitors of SARS-CoV-2 nsp5 main protease, finding calpain inhibitor I and peptidyl fluoromethylketones with potent antiviral activity.
bioRxiv · Apr 7, 2021Biochemistry
Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp14/nsp10 Exoribonuclease
C. Basier, S. Basu, R. Beale, A. P. Bertolin, B. Canal, J. F. Curran, T. D. Deegan, J. F. Diffley, L. S. Drury, R. Fujisawa, M. Howell, K. Labib, A. W. McClure, J. Milligan, E. Roberts, , J. Zeng
This study identifies patulin and aurintricarboxylic acid as inhibitors of SARS-CoV-2 nsp14 exoribonuclease, showing antiviral activity in cell culture.
bioRxiv · Apr 7, 2021Biochemistry
Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp15 Endoribonuclease
R. Beale, A. P. Bertolin, B. Canal, T. D. Deegan, J. F. Diffley, L. S. Drury, R. Fujisawa, M. Howell, K. Labib, A. W. McClure, R. Ulferts, F. Weissmann, M. Wu, J. Zeng
This study screens for small molecule inhibitors of SARS-CoV-2 nsp15 endoribonuclease and identifies NSC95397 as an in vitro inhibitor, though its antiviral efficacy remains to be determined.
bioRxiv · Apr 7, 2021Biochemistry
Identification of SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of the nsp14 RNA Cap Methyltransferase
C. Basier, S. Basu, R. Beale, B. Canal, V. H. Cowling, J. F. Curran, T. D. Deegan, J. F. Diffley, L. S. Drury, R. Fujisawa, M. Howell, K. Labib, C. T. Lim, T. Mak, A. W. McClure, , T. U. Zeisner
This study identifies four small molecule inhibitors of SARS-CoV-2 nsp14 RNA cap methyltransferase, with three showing synergy with remdesivir in antiviral assays.
bioRxiv · Apr 7, 2021Bioengineering
Dose old age lead to gluttony? Effects of aging on predation and locomotion in the assassin bug Amphibolus venator.
T. Miyatake, K. Matsumura, M. Iwaya, N. Nagaya, R. Fujisawa
This study examines how aging affects locomotor activity and foraging ability in the assassin bug Amphibolus venator, finding that while locomotor activity decreases, foraging ability increases with age.
bioRxiv · Dec 16, 2019 · PreprintAnimal Behavior & Cognition
DNA replication stress induced by trifluridine determines tumor cell fate according to p53 status
Y. Kataoka, M. Iimori, R. Fujisawa, T. Morikawa-Ichinose, S. Niimi, T. Wakasa, H. Saeki, E. Oki, D. Miura, T. Tsurimoto, Y. Maehara, H. Kitao
This paper shows that trifluridine induces DNA replication stress that leads to different cell fates in tumor cells depending on their p53 status.
bioRxiv · Sep 13, 2019Cancer Biology
Regulatory mechanism predates the evolution of ant-like swarm intelligence in simulated robots
R. Fujisawa, G. Ichinose, S. Dobata
This study shows that regulatory behavior in simulated robot swarms precedes the evolution of ant-like swarm intelligence by helping bypass fitness valleys caused by overcrowding.
bioRxiv · Jul 23, 2018Evolutionary Biology