Author

H. Staples

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:non-human primate· 2 Assay:clinical cohort / trial· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

M. Gazi· 3 shared B. Klaffke· 2 shared C. Bartley· 2 shared C. Hallam· 2 shared K. J. Alfson· 2 shared L. Parodi· 2 shared O. Gonzalez· 2 shared P. Escareno· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

M. Gazi

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Development of a Well-Characterized Cynomolgus Macaque Model of Sudan Virus Disease for Support of Product Development

K. J. Alfson, Y. Goez-Gazi, M. Gazi, Y.-L. Chou, N. A. Niemuth, M. E. Mattix, H. Staples, B. Klaffke, G. F. Rodriguez, P. Escareno, C. Bartley, A. Ticer, E. A. Clemmons, J. W. Dutton, A. Griffiths, , R. Carrion

This study characterizes the disease course in cynomolgus macaques infected with Sudan virus to evaluate its suitability as a model for filovirus countermeasure development under the FDA Animal Rule.

bioRxiv · May 4, 2022Microbiology

Lethality of SARS-CoV-2 infection in K18 human angiotensin converting enzyme 2 transgenic mice

F. Oladunni, J.-G. Park, P. Pino Tamayo, O. Gonzalez, A. Ahkter, A. Allue Guardia, A. Olmo-Fontanez, S. Gautam, A. Garcia Vilanova, C. Ye, K. Chiem, C. Headley, V. Dwivedi, L. Parodi, K. Alfson, , J. B. Torrelles

This study demonstrates that K18 hACE2 transgenic mice are susceptible to SARS-CoV-2 infection, exhibit cytokine and chemokine storms, and serve as a model for studying viral pathogenesis and therapeutic development.

bioRxiv · Jul 18, 2020Microbiology

SARS-CoV-2 infection leads to acute infection with dynamic cellular and inflammatory flux in the lung that varies across nonhuman primate species

D. K. Singh, S. R. Ganatra, B. Singh, J. Cole, K. J. Alfson, E. Clemmons, M. Gazi, O. Gonzalez, R. Escabedo, T.-H. Lee, A. Chatterjee, Y. Goez-Gazi, R. Sharan, R. Thippeshappa, M. Gough, , M

This study compares SARS-CoV-2 infection in three nonhuman primate species, showing varied disease progression and immune responses.

bioRxiv · Jun 5, 2020Immunology