Author

S. Gautam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 3 Biophysics· 2 Cell Biology· 2 Animal Behavior & Cognition· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 12 Research Focus:host-pathogen & immune response· 8 Organism:mouse· 5 Research Focus:cell signaling & trafficking· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

J. B. Torrelles· 3 shared J. Turner· 3 shared V. Dwivedi· 3 shared A. Schami· 2 shared C. A. Headley· 2 shared F.-U. Hartl· 2 shared K. Chiem· 2 shared L. Martinez-Sobrido· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersImmunology

J. B. Torrelles

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12 papers

Recent·Most cited

ClearX9™: an efficient alternative to fetal bovine serum for growing animal cells in vitro

S. Gautam, N. Verma, S. Manvati, P. K. Dhar

This paper introduces ClearX9 as a sustainable alternative to fetal bovine serum for growing animal cells in vitro, showing comparable growth and health benefits.

bioRxiv · May 1, 2023 · PreprintCell Biology

Evaluation of the safety, immunogenicity and efficacy of a new live-attenuated lumpy skin disease vaccine in India

N. Kumar, S. Barua, R. Kumar, N. Khandelwal, A. Kumar, A. Verma, L. Singh, B. Godara, Y. Chander, T. Riyesh, D. K. Sharma, A. Pathak, S. Kumar, R. K. Dedar, V. Mehta, , B. N. Tripathi

This study evaluates a new live-attenuated LSD vaccine, showing it is safe, immunogenic, and effective in protecting cattle against LSD with high seroconversion rates.

bioRxiv · Dec 10, 2022Microbiology

The Drosophila Dopamine 2-like receptor D2R (Dop2R) is required in the Blood Brain Barrier for male courtship

C. R. Love, S. Gautam, C. Lama, N. H. Le, B. Dauwalder

This study shows that the D2R dopamine receptor in Drosophila BBB glial cells is essential for normal male courtship behavior.

bioRxiv · Nov 22, 2022 · PreprintAnimal Behavior & Cognition

A dual role for CRTH2 in acute lung injury

S. Bhattacharya, N. Ristic, A. J. Cohen, D. Tsang, M. Gwin, R. Howell, G. Young, E. Jung, C. S. Dela Cruz, S. Gautam

This study investigates CRTH2's role in acute lung injury, finding it promotes neutrophil survival but suppresses neutrophilic inflammation via IL-4.

bioRxiv · May 29, 2022 · PreprintImmunology

The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds

I. Saha, P. Yuste-Checa, M. da Silva Padilha, Q. Guo, R. Körner, H. Holthusen, V. A. Trinkaus, I. Dudanova, R. Fernandez-Busnadiego, W. Baumeister, D. W. Sanders, S. Gautam, M. I. Diamond, F.-U. Hartl, M. S. Hipp

This study shows that the AAA+ chaperone VCP disaggregates Tau fibrils and generates seeding-active Tau as a byproduct, suggesting a role in aggregate removal and spreading in tauopathies.

bioRxiv · Feb 18, 2022Cell Biology

Homeostatic control of c-di-AMP synthase (MsDisA) and hydrolase (MsPDE) from Mycobacterium smegmatis

S. Gautam, A. Mahapa, L. Yeramala, A. Gandhi, S. Krishnan, V. R. Kutti, D. Chatterji

This study characterizes the c-di-AMP synthase (MsDisA) and hydrolase (MsPDE) from M. smegmatis under different pH and osmolytic conditions, revealing their biochemical and structural regulation in response to environmental stress.

bioRxiv · Nov 20, 2021 · PreprintBiophysics

IL-10 receptor blockade delivered simultaneous with BCG vaccination sustains long term protection against Mycobacterium tuberculosis infection in mice

V. Dwivedi, S. Gautam, C. A. Headley, T. Piergallini, J. B. Torrelles, J. Turner

This study shows that combining BCG vaccination with IL-10 receptor blockade in mice provides long-term protection against M.tb infection, improving T cell responses and survival.

bioRxiv · Sep 5, 2021Immunology

Extracellular Delivery of Functional Mitochondria Rescues the Dysfunction of CD4+ T Cells in Aging.

C. A. Headley, S. Gautam, A. M. Olmo-Fontanez, A. M. Garcia-Vilanova, V. Dwivedi, A. Akhter, A. Schami, K. Chiem, R. Ault, H. Zhang, H. Cai, A. A. Whigham, J. A. Delgado, A. A. Hicks, P. Tsao, , J. Turner

This study transfers functional mitochondria into aged CD4+ T cells, improving their metabolism, reducing oxidative stress, and enhancing immune function against infections.

bioRxiv · Feb 21, 2021Immunology

An Abundant New Saponin-Polybromophenol Antibiotic (CU1) from Cassia fistula Bark Against Multi-Drug Resistant Bacteria Targeting RNA Polymerase

A. K. CHAKRABORTY, S. Saha, K. Poria, T. Samanta, S. Gautam, J. Mukopadhyay

The paper identifies a new saponin-polybromophenol compound (CU1) from Cassia fistula bark that inhibits RNA polymerase in MDR bacteria, showing potential as an alternative antibiotic.

bioRxiv · Nov 4, 2020 · PreprintMicrobiology

The Hsc70 Disaggregation Machinery RemovesMonomer Units Directly from α-Synuclein FibrilEnds

M. M. Schneider, S. Gautam, T. W. Herling, E. Andrzejwska, G. Krainer, A. M. Miller, Q. A. E. Peter, F. S. Ruggeri, M. Vendruscolo, A. Bracher, C. M. Dobson, F.-U. Hartl, T. Knowles

This study shows the Hsc70-DnaJB1-Apg2 chaperone system removes monomer units directly from α-synuclein fibril ends, reversing aggregation without intermediate fragmentation.

bioRxiv · Nov 2, 2020Biophysics

Lethality of SARS-CoV-2 infection in K18 human angiotensin converting enzyme 2 transgenic mice

F. Oladunni, J.-G. Park, P. Pino Tamayo, O. Gonzalez, A. Ahkter, A. Allue Guardia, A. Olmo-Fontanez, S. Gautam, A. Garcia Vilanova, C. Ye, K. Chiem, C. Headley, V. Dwivedi, L. Parodi, K. Alfson, , J. B. Torrelles

This study demonstrates that K18 hACE2 transgenic mice are susceptible to SARS-CoV-2 infection, exhibit cytokine and chemokine storms, and serve as a model for studying viral pathogenesis and therapeutic development.

bioRxiv · Jul 18, 2020Microbiology

Determination of Cas9/dCas9 associated toxicity in microbes

C. S. Misra, G. Bindal, M. Sodani, S. Wadhawan, S. Kulkarni, S. Gautam, R. Mukhopadhyaya, D. Rath

The paper assesses Cas9 and dCas9 toxicity in five microbes by measuring plasmid transformation efficiency, finding differential toxicity levels across species.

bioRxiv · Nov 20, 2019 · PreprintMicrobiology