Exploitation of CD3ζ to enhance TCR expression levels and antigen-specific T cell function
A. Degirmencay, S. Thomas, A. Holler, H. Stauss
This study shows that CD3ζ enhances TCR surface expression and function in human T cells by increasing endogenous TCRβ expression and reducing mispairing with endogenous chains.
bioRxiv · Feb 14, 2024Immunology