R. K. Gupta

Preservation of memory B cell homeostasis in an individual producing broadly neutralising antibodies against HIV-1

The paper isolates a broadly neutralizing HIV-1 antibody from an untreated HIV-1 patient and shows memory B cells remain functional despite viral infection.

Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through multiple mechanisms

This study investigates how N354 glycosylation in the SARS-CoV-2 spike protein affects viral fitness and human adaptation through multiple mechanisms.

CD4 T cell contact drives macrophage cell cycle progression and susceptibility to lentiviral transduction

The paper shows that CD4 T cell contact induces macrophage cell cycle progression from G0 to G1, increasing their susceptibility to lentiviral transduction.

Hypoxia drives HIF2-dependent macrophage cell cycle entry and susceptibility to lentiviral transduction

This study shows hypoxia induces HIF2-dependent cell cycle entry in macrophages, leading to increased susceptibility to lentiviral transduction and is observed in tumor-associated macrophages.

GPR84-Mediated Signal Transduction Promotes Brown Adipocyte Function

This study shows that GPR84 promotes brown adipocyte function by regulating mitochondrial calcium and respiration, with implications for metabolic disease treatment.

Cell cycle independent role of cyclin D3 in host restriction of SARS-CoV-2 infection

This study shows that cyclin D3 depletion during SARS-CoV-2 infection enhances virus titres and is independent of cell cycle arrest, suggesting a role in restricting viral assembly.

SARS-CoV-2 Spike N-Terminal Domain modulates TMPRSS2-dependent viral entry and fusogenicity

This study examines how mutations in the SARS-CoV-2 Spike N-Terminal Domain affect viral entry and fusogenicity, showing context-dependent modulation of spike function.

The origins and molecular evolution of SARS-CoV-2 lineage B.1.1.7 in the UK

This study investigates the origins and molecular evolution of SARS-CoV-2 lineage B.1.1.7 (Alpha) in the UK, finding that a chronically-infected immunocompetent individual likely drove its rapid mutation and spread.

Selection analysis identifies unusual clustered mutational changes in Omicron lineage BA.1 that likely impact Spike function

The paper identifies 13 rare mutations in the Omicron S-gene that cluster in functionally important regions and likely impact Spike function, suggesting cooperative interactions that mitigate fitness costs.

High throughput hemogram of T cells using digital holographic microscopy and deep learning

This study uses digital holographic microscopy and deep learning to classify CD4+ and CD8+ T cells with high throughput and accuracy.

FXR inhibition reduces ACE2 expression, SARS-CoV-2 infection and may improve COVID-19 outcome

This study shows FXR inhibition lowers ACE2 expression, reduces SARS-CoV-2 infection, and correlates with better clinical outcomes in COVID-19.

Evidence Of We-Representation In Monkeys When Acting Together

The paper shows that macaques improve joint-action performance when cued about future collaborative actions, indicating a 'we-representation' in collective behavior.

The impact of Spike mutations on SARS-CoV-2 neutralization

This study evaluates how Spike mutations in SARS-CoV-2 variants affect neutralization by monoclonal and polyclonal antibodies, showing reduced activity in some cases.

Adiponectin Preserves Metabolic Fitness During Aging

This study shows that adiponectin improves healthspan and lifespan by enhancing insulin sensitivity and reducing age-related metabolic and inflammatory disorders in mice.

Recurrent emergence and transmission of a SARS-CoV-2 Spike deletion H69/V70

This paper identifies a recurrent SARS-CoV-2 Spike deletion (H69/V70) that increases infectivity and compensates for RBD mutations, suggesting it may facilitate immune escape and variant emergence.

Extended in vitro inactivation of SARS-CoV-2 by titanium dioxide surface coating

This study demonstrates that titanium dioxide-coated surfaces can inactivate SARS-CoV-2 under ambient light within 5 hours of exposure.

In Vivo Emergence of a Novel Protease Inhibitor Resistance Signature in HIV-1 Matrix

The paper identifies a novel protease inhibitor resistance signature in HIV-1 matrix through genotypic and phenotypic analysis of patients failing PI therapy.

IFN-independent cell cycle arrest and SAMHD1 activation following TLR4 activation in macrophages

This study shows TLR4 activation in macrophages induces G0 arrest and SAMHD1 activation independently of IFN, blocking HIV-1 infection through SAMHD1.

Concise whole blood transcriptional signatures for incipient tuberculosis: A systematic review and patient-level pooled meta-analysis

This paper evaluates 17 mRNA signatures for predicting incipient tuberculosis using a pooled dataset of 1,026 samples, finding that eight signatures show moderate diagnostic accuracy but fall short of WHO benchmarks for long-term risk prediction.

Clonal replacement of tumor-specific T cells following PD-1 blockade

This study tracks T cell clonal dynamics before and after PD-1 blockade in cancer patients, finding that new T cell clones, not pre-existing ones, expand in response to treatment.