Author

J. Heaney

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Assay:proteomics· 3 Assay:DNA methylation· 1 Organism:virus· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

E. Nastouli· 4 shared A. Rosa· 3 shared H. Rickman· 3 shared J. Mccauley· 3 shared N. Faulkner· 3 shared R. Harvey· 3 shared S. Gamblin· 3 shared S. Hussain· 3 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

E. Nastouli

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains

N. Faulkner, K. Ng, M. Wu, R. Harvey, S. Hussain, M. Greco, W. Bolland, S. Warchal, M. Margaritis, S. Paraskevopoulou, J. Heaney, H. Rickman, C. Houlihan, M. Spyer, D. Frampton, , G. Kassiotis

This study compares antibody cross-reactivity between SARS-CoV-2 B.1.1.7 and parental strains, finding reduced recognition and neutralization of older variants after B.1.1.7 infection.

bioRxiv · Mar 1, 2021Immunology

Favourable antibody responses to human coronaviruses in children and adolescents with autoimmune rheumatic diseases

C. Deakin, G. Cornish, K. Ng, N. Faulkner, W. Bolland, V. Panova, J. Hope, A. Rosa, R. Harvey, S. Hussain, C. Earl, B. Jebson, M. Wilkinson, L. Marshall, K. O'Brien, , G. Kassiotis

The paper examines antibody responses to HCoV-OC43 and SARS-CoV-2 in children with autoimmune rheumatic diseases, finding stronger spike antibody responses and cross-reactivity despite immunosuppressive treatment.

bioRxiv · Feb 15, 2021 · PreprintImmunology

The impact of Spike mutations on SARS-CoV-2 neutralization

C. Rees-Spear, L. Muir, S. A. Griffith, J. Heaney, Y. Aldon, J. Snitselaar, P. Thomas, C. Graham, J. Seow, N. Lee, A. Rosa, C. Roustan, C. F. Houlihan, R. W. Sanders, R. K. Gupta, , L. E. McCoy

This study evaluates how Spike mutations in SARS-CoV-2 variants affect neutralization by monoclonal and polyclonal antibodies, showing reduced activity in some cases.

bioRxiv · Jan 15, 2021 · PreprintImmunology

Portable real-time colorimetric LAMP-device for rapidquantitative detection of nucleic acids in crude samples

G. Papadakis, A. K. Pantazis, N. Fikas, S. Chatziioannidou, V. Tsiakalou, K. Michaelidou, V. Pogka, M. Megariti, M. Vardaki, K. Giarentis, J. Heaney, E. Nastouli, T. Karamitros, A. Mentis, A. Zafiropoulos, , E. Gizeli

The paper develops a portable real-time colorimetric LAMP device for rapid, quantitative nucleic acid detection in crude samples with high sensitivity and specificity.

bioRxiv · Jul 22, 2020Bioengineering

Pre-existing and de novo humoral immunity to SARS-CoV-2 in humans

K. W. Ng, N. Faulkner, G. Cornish, A. Rosa, R. Harvey, S. Hussain, R. Ulferts, C. Earl, A. Wrobel, D. Benton, C. Roustan, W. Bolland, R. Thompson, A. Agua-Doce, P. Hobson, , Mc

The paper identifies pre-existing and de novo humoral immunity to SARS-CoV-2 in humans, showing that uninfected individuals have SARS-CoV-2 S-reactive antibodies, particularly in children, and that infection leads to higher antibody titres targeting multiple subunits.

bioRxiv · May 14, 2020Immunology