Author

H. T. Gilbert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

J. Swift· 4 shared S. M. Richardson· 3 shared V. Mallikarjun· 3 shared J. Llewellyn· 2 shared M. R. Jackson· 2 shared O. Dobre· 2 shared A. P. Gilmore· 1 shared D. J. Beech· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersCell Biology

J. Swift

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Author profile →

4 papers

Recent·Most cited

Loss of cytoskeletal proteostasis links dysregulation of cell size and mechanotransduction in mesenchymal stem cell senescence

V. Mallikarjun, O. Dobre, M. R. Jackson, M. Kidd, J. Llewellyn, H. T. Gilbert, S. M. Richardson, J. Swift

This study shows that loss of cytoskeletal proteostasis in senescent mesenchymal stem cells disrupts mechanotransduction and matrix protein secretion, linking cell size dysregulation to tissue maintenance issues.

bioRxiv · Oct 9, 2022 · PreprintCell Biology

Senescence inhibits the chaperone response to thermal stress

J. Llewellyn, V. Mallikarjun, E. Appleton, M. Osipova, H. T. Gilbert, S. M. Richardson, S. J. Hubbard, J. Swift

The paper shows that senescence impairs the chaperone response to thermal stress in human mesenchymal stem cells, leading to misfolded protein accumulation.

bioRxiv · Jun 15, 2021 · PreprintCell Biology

Stimulation of cardiac fibroblast Piezo1 channels opposes myofibroblast differentiation and induces IL-6 secretion via Ca2+-mediated p38 MAP kinase activation

N. M. Blythe, V. Stylianidis, M. J. Ludlow, H. T. Gilbert, E. L. Evans, K. Cuthbertson, R. Foster, J. Swift, J. Li, M. J. Drinkhill, F. A. van Nieuwenhoven, K. E. Porter, D. J. Beech, N. A. Turner

This study shows that activating Piezo1 channels in cardiac fibroblasts reduces myofibroblast differentiation and increases IL-6 secretion through Ca2+-dependent p38 MAP kinase activation.

bioRxiv · Apr 10, 2019Cell Biology

Nuclear decoupling is part of a rapid protein-level cellular response to high-intensity mechanical loading

H. T. Gilbert, V. Mallikarjun, O. Dobre, M. R. Jackson, R. Pedley, A. P. Gilmore, S. M. Richardson, J. Swift

The paper investigates how human mesenchymal stem cells respond to mechanical loading by decoupling nuclear and cytoskeletal mechano-transmission at the protein level.

bioRxiv · May 9, 2018Biophysics