Author

O. Dobre

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioengineering· 2 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

J. Swift· 3 shared S. M. Richardson· 3 shared H. T. Gilbert· 2 shared M. R. Jackson· 2 shared V. Mallikarjun· 2 shared A. Galarza Torre· 1 shared A. Khan· 1 shared A. P. Gilmore· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCell Biology

J. Swift

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Engineered 3D environments reprogram fibroblast-mediated inflammation in rheumatoid Arthritis.

A. Khan, P. Pan, J. Isakova, Y. Lan, C. Cil, Y. Wang, T. Rogkoti, T. Sartyoungkul, J. Windmill, J. A. Williams, M. Salmeron-Sanchez, M. M. Harnett, O. Dobre, M. Pineda

This study shows that 3D environments influence fibroblast inflammation in rheumatoid arthritis, with soft hydrogels promoting a resolving phenotype and stiff scaffolds restoring inflammatory profiles.

bioRxiv · Dec 21, 2022 · PreprintBioengineering

Loss of cytoskeletal proteostasis links dysregulation of cell size and mechanotransduction in mesenchymal stem cell senescence

V. Mallikarjun, O. Dobre, M. R. Jackson, M. Kidd, J. Llewellyn, H. T. Gilbert, S. M. Richardson, J. Swift

This study shows that loss of cytoskeletal proteostasis in senescent mesenchymal stem cells disrupts mechanotransduction and matrix protein secretion, linking cell size dysregulation to tissue maintenance issues.

bioRxiv · Oct 9, 2022 · PreprintCell Biology

Nuclear decoupling is part of a rapid protein-level cellular response to high-intensity mechanical loading

H. T. Gilbert, V. Mallikarjun, O. Dobre, M. R. Jackson, R. Pedley, A. P. Gilmore, S. M. Richardson, J. Swift

The paper investigates how human mesenchymal stem cells respond to mechanical loading by decoupling nuclear and cytoskeletal mechano-transmission at the protein level.

bioRxiv · May 9, 2018Biophysics

An immortalised mesenchymal stem cell line maintains mechano-responsive behaviour and can be used as a reporter of substrate stiffness

A. Galarza Torre, J. E. Shaw, A. Wood, H. T. J. Gilbert, O. Dobre, P. Genever, K. Brennan, S. M. Richardson, J. Swift

The paper shows that an immortalized mesenchymal stem cell line retains mechano-responsiveness and can serve as a reporter for substrate stiffness.

bioRxiv · Feb 21, 2018Bioengineering