Author

V. Mallikarjun

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Biophysics· 2 Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Assay:proteomics· 9 Research Focus:cell signaling & trafficking· 5 Research Focus:cell type annotation· 5 Organism:human· 5 Organism:mouse· 4 Assay:bulk RNA-seq· 2 Approach:statistical model· 2

Frequent Co-Authors

J. Swift· 9 shared H. T. Gilbert· 3 shared K. E. Kadler· 3 shared S. M. Richardson· 3 shared A. P. Gilmore· 2 shared A. Pickard· 2 shared C.-Y. C. Yeung· 2 shared D. F. Holmes· 2 shared

Activity by Year

2018-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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9 shared papersCell Biology

J. Swift

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Loss of cytoskeletal proteostasis links dysregulation of cell size and mechanotransduction in mesenchymal stem cell senescence

V. Mallikarjun, O. Dobre, M. R. Jackson, M. Kidd, J. Llewellyn, H. T. Gilbert, S. M. Richardson, J. Swift

This study shows that loss of cytoskeletal proteostasis in senescent mesenchymal stem cells disrupts mechanotransduction and matrix protein secretion, linking cell size dysregulation to tissue maintenance issues.

bioRxiv · Oct 9, 2022 · PreprintCell Biology

Mmp14 is required for matrisome homeostasis and circadian rhythm in fibroblasts

C.-Y. C. Yeung, R. Garva, A. Pickard, Y. Lu, V. Mallikarjun, J. Swift, S. H. Taylor, J. Rai, D. R. Eyre, M. Chaturvedi, Y. Itoh, Q.-J. Meng, C. Mauch, P. Zigrino, K. E. Kadler

This study shows that Mmp14 regulates circadian rhythms and matrisome homeostasis in tendon fibroblasts by controlling collagen fibril synthesis and crosslinking.

bioRxiv · Apr 1, 2022Cell Biology

Senescence inhibits the chaperone response to thermal stress

J. Llewellyn, V. Mallikarjun, E. Appleton, M. Osipova, H. T. Gilbert, S. M. Richardson, S. J. Hubbard, J. Swift

The paper shows that senescence impairs the chaperone response to thermal stress in human mesenchymal stem cells, leading to misfolded protein accumulation.

bioRxiv · Jun 15, 2021 · PreprintCell Biology

BioID based proteomic analysis of the Bid interactome identifies novel proteins involved in cell cycle dependent apoptotic priming.

R. Pedley, L. King, V. Mallikarjun, P. Wang, J. Swift, K. Brennan, A. P. Gilmore

The paper uses BioID to identify novel Bid interactors involved in cell cycle-dependent apoptotic priming, highlighting VDAC2's role in Bid phosphorylation and sensitivity to anti-mitotic drugs.

bioRxiv · Feb 7, 2020Cell Biology

Laser capture microdissection coupled mass spectrometry (LCM-MS) for spatially resolved analysis of formalin-fixed and stained human lung tissues

J. A. Herrera, V. Mallikarjun, S. Rosini, M. A. Montero, S. Warwood, R. O'Caulian, D. Knight, M. A. Schwartz, J. Swift

This paper develops an optimized microproteomics method for analyzing H&E-stained FFPE lung tissues, identifying 1252 differentially expressed proteins including 137 ECM proteins.

bioRxiv · Aug 13, 2019Biochemistry

Circadian time series proteomics reveals daily dynamics in cartilage physiology

M. Dudek, C. Angelucci, J. P. Ruckshanthi, P. Wang, V. Mallikarjun, C. Lawless, K. E. Kadler, J. A. Hoyland, S. R. Lamande, J. F. Bateman, Q.-J. Meng

This study uses circadian time-series proteomics to identify daily protein abundance changes in mouse articular cartilage, revealing rhythmic proteins and their dysregulation in osteoarthritis and aging.

bioRxiv · May 31, 2019Physiology

Circadian control of the secretory pathway is a central mechanism in tissue homeostasis

J. Chang, R. Garva, A. Pickard, C.-Y. C. Yeung, V. Mallikarjun, J. Swift, D. F. Holmes, B. Calverley, Y. Lu, A. Adamson, H. Raymond-Hayling, O. Jensen, T. Shearer, Q. J. Meng, K. E. Kadler

The paper identifies a circadian mechanism regulating collagen synthesis, assembly, and degradation to maintain tissue homeostasis in mice.

bioRxiv · Apr 7, 2019Cell Biology

Distinct matrix composition and mechanics in aged and estrogen-deficient mouse skin

C. R. Saville, V. Mallikarjun, D. F. Holmes, E. Emmerson, B. Derby, J. Swift, M. J. Sherratt, M. J. Hardman

This study examines how aging and estrogen deficiency affect skin matrix composition and mechanics in mice, finding contrasting effects on tensile strength and collagen levels.

bioRxiv · Mar 8, 2019 · PreprintBiophysics

microRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis

A. Moro, T. Driscoll, W. Armero, L. C. Boraas, D. Kasper, N. Baeyens, C. Jouy, V. Mallikarjun, J. Swift, S. J. Ahn, D. Lee, J. Zhang, M. Gu, M. Gerstein, M. Schwartz, S. Nicoli

The paper identifies microRNA-dependent regulation of biomechanical genes that maintain tissue stiffness homeostasis through cytoskeletal and extracellular matrix control.

bioRxiv · Jul 3, 2018Cell Biology

Nuclear decoupling is part of a rapid protein-level cellular response to high-intensity mechanical loading

H. T. Gilbert, V. Mallikarjun, O. Dobre, M. R. Jackson, R. Pedley, A. P. Gilmore, S. M. Richardson, J. Swift

The paper investigates how human mesenchymal stem cells respond to mechanical loading by decoupling nuclear and cytoskeletal mechano-transmission at the protein level.

bioRxiv · May 9, 2018Biophysics