Author

H. V. Goodson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Biophysics· 1 Cancer Biology· 1 Ecology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Assay:imaging· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Research Focus:ecology & biodiversity· 1 Organism:human· 1 Assay:metagenomics· 1

Frequent Co-Authors

E. M. Jonasson· 3 shared Y.-F. O. Wu· 3 shared A. J. Mauro· 2 shared N. T. Nelson· 2 shared A. Cervantes· 1 shared A. G. Madey· 1 shared A. J. Marrs· 1 shared A. T. Bryant· 1 shared

Activity by Year

2019-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersBiochemistry

E. M. Jonasson

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Overexpression of the microtubule-binding protein CLIP-170 induces a +TIP network superstructure consistent with a biomolecular condensate

Y.-F. O. Wu, A. T. Bryant, N. T. Nelson, A. G. Madey, G. F. Fernandes, H. V. Goodson

This study shows that overexpressed CLIP-170 forms phase-separated liquid condensates containing +TIPs, suggesting the +TIP network can function as a biomolecular condensate.

PLOS ONE · Dec 10, 2021Peer-reviewedCell Biology

Characterizing interactions between the microtubule-binding protein CLIP-170 and F-actin

Y.-F. O. Wu, R. A. Miller, E. O. Alberico, N. T. Nelson, E. M. Jonasson, H. V. Goodson

This study shows CLIP-170 directly binds F-actin, independent of formin interaction, and suggests this binding may reduce MT stability in actin-rich regions.

bioRxiv · Apr 27, 2021 · PreprintBiochemistry

Development of a yeast-based assay for bioavailable phosphorus

H. A. M. Shepherd, M. T. Trentman, J. L. Tank, J. Praner, A. Cervantes, P. Chaudhary, J. Gezelter, A. J. Marrs, K. A. Myers, J. R. Welsh, Y.-F. O. Wu, H. V. Goodson

The paper develops a yeast-based assay to measure bioavailable phosphorus in freshwater, showing it is cost-effective, nonhazardous, and compatible with real-world samples.

bioRxiv · Feb 28, 2021 · PreprintEcology

Quantification of Microtubule Stutters: Dynamic Instability Behaviors that are Strongly Associated with Catastrophe

S. M. Mahserejian, J. P. Scripture, A. J. Mauro, E. J. Lawrence, E. M. Jonasson, K. S. Murray, J. Li, M. K. Gardner, M. Alber, M. Zanic, H. V. Goodson

The paper introduces STADIA, a tool to quantify microtubule dynamics, including stutters, and shows stutters precede catastrophes, with CLASP2{gamma} promoting their return to growth.

bioRxiv · Dec 16, 2019Cell Biology

Imatinib overrides taxane resistance by selective inhibition of novel CLIP1 variant obstructing the microtubule pore

K. Kita, P. V. Thakkar, G. Galletti, N. Madhukar, E. V. Navarro, I. Barasoain, H. V. Goodson, D. Sackett, J. F. Diaz, O. Elemento, M. A. Shah, P. Giannakakou

The paper identifies a novel CLIP-170 variant, CLIP-170S, that causes taxane resistance in gastric cancer and shows imatinib can reverse this resistance by selectively inhibiting CLIP-170S.

bioRxiv · Nov 11, 2019 · PreprintCancer Biology

Relationship between Dynamic Instability of Individual Microtubules and Flux of Subunits into and out of Polymer

A. J. Mauro, E. M. Jonasson, H. V. Goodson

The paper derives and compares different forms of the J equation relating bulk polymer flux to individual filament dynamics using simulations and derivations.

bioRxiv · Apr 16, 2019Biophysics