A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective
H. W. Ong, Y. Liang, W. Richardson, E. R. Lowry, C. I. Wells, X. Chen, M. Silvestre, K. Dempster, J. A. Silvaroli, J. L. Smith, H. Wichterle, N. S. Pabla, S. K. Ultanir, A. N. Bullock, D. Drewry, A. D. Axtman
The paper develops a potent and selective CDKL5/GSK3 chemical probe and demonstrates its neuroprotective effects in human motor neurons under ER stress.
bioRxiv · Feb 9, 2023 · PreprintCell Biology