Vascular Smooth Muscle Cell Mechanotransduction Through Serum and Glucocorticoid Inducible Kinase-1 Promotes Interleukin-6 Production and Macrophage Accumulation in Murine Hypertension
M. Figueroa, S. Hall, V. Mattia, A. Mendoza, A. Brown, Y. Xiong, R. Mukherjee, J. A. Jones, W. Richardson, J. M. Ruddy
This study shows that SGK-1 in vascular smooth muscle cells promotes IL-6 and macrophage accumulation in hypertension via mechanotransduction and AngII signaling.
bioRxiv · Mar 3, 2023 · PreprintPhysiology