Author

J. A. Silvaroli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

N. S. Pabla· 3 shared A. D. Axtman· 2 shared A. N. Bullock· 2 shared C. I. Wells· 2 shared D. Drewry· 2 shared S. K. Ultanir· 2 shared X. Chen· 2 shared A. Bajwa· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCell Biology

N. S. Pabla

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2

F. M. Bashore, S. M. Min, X. Chen, S. Howell, C. H. Rinderle, G. Morel, J. A. Silvaroli, C. I. Wells, B. A. Bunnell, D. Drewry, N. S. Pabla, S. K. Ultanir, A. N. Bullock, A. D. Axtman

The paper identifies and characterizes a chemical probe for CDKL2, demonstrating its selectivity and biological impact in neurons and cancer cells.

bioRxiv · May 12, 2024Cell Biology

A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective

H. W. Ong, Y. Liang, W. Richardson, E. R. Lowry, C. I. Wells, X. Chen, M. Silvestre, K. Dempster, J. A. Silvaroli, J. L. Smith, H. Wichterle, N. S. Pabla, S. K. Ultanir, A. N. Bullock, D. Drewry, A. D. Axtman

The paper develops a potent and selective CDKL5/GSK3 chemical probe and demonstrates its neuroprotective effects in human motor neurons under ER stress.

bioRxiv · Feb 9, 2023 · PreprintCell Biology

Nephrotoxicity of the BRAF-kinase inhibitor Vemurafenib isdriven by off-target Ferrochelatase inhibition

Y. Bai, J. Y. Kim, L. A. Jayne, M. Gandhi, K. M. Huang, J. A. Silvaroli, V. Sander, J. Prosek, K. D. Jhaveri, S. D. Baker, A. Sparreboom, A. Bajwa, N. S. Pabla

This study identifies off-target ferrochelatase inhibition as a mechanism of vemurafenib-induced nephrotoxicity in renal tubular epithelial cells.

bioRxiv · Jan 29, 2021 · PreprintPharmacology & Toxicology