IL-22 promotes acute kidney injury through activation of the DNA damage response and cell death in proximal tubule cells
K. Taguchi, S. Sugahara, B. C. Elias, N. S. Pabla, G. Canaud, C. R. Brooks
bioRxiv · Jun 8, 2023 · PreprintCell Biology
Author
N. S. Pabla
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
Click to filter author papersSignature Assays, Organisms & Methods
Click to filter · or open tagActivity by Year
2020-2023 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 21 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship5 papers
Recent·Most cited
A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective
H. W. Ong, Y. Liang, W. Richardson, E. R. Lowry, C. I. Wells, X. Chen, M. Silvestre, K. Dempster, J. A. Silvaroli, J. L. Smith, H. Wichterle, N. S. Pabla, S. K. Ultanir, A. N. Bullock, D. Drewry, A. D. Axtman
The paper develops a potent and selective CDKL5/GSK3 chemical probe and demonstrates its neuroprotective effects in human motor neurons under ER stress.
bioRxiv · Feb 9, 2023 · PreprintCell Biology
Tubular Mitochondrial Pyruvate Carrier Disruption Elicits Redox Adaptations that Protect from Acute Kidney Injury
A. Rauckhorst, G. V. Martinez, G. M. Andrade, H. Wen, J. Y. Kim, A. Simoni, K. A. Mapuskar, P. Rastogi, E. J. Steinbach, M. L. McCormick, B. G. Allen, A. R. Jackson, N. S. Pabla, M. C. Coleman, D. R. Spitz, , D. Zepeda-Orozco
The paper shows that reducing mitochondrial pyruvate carrier activity in kidney tubular cells protects against acute kidney injury by enhancing redox defenses and survival.
bioRxiv · Jan 31, 2023Biochemistry
Nephrotoxicity of the BRAF-kinase inhibitor Vemurafenib isdriven by off-target Ferrochelatase inhibition
Y. Bai, J. Y. Kim, L. A. Jayne, M. Gandhi, K. M. Huang, J. A. Silvaroli, V. Sander, J. Prosek, K. D. Jhaveri, S. D. Baker, A. Sparreboom, A. Bajwa, N. S. Pabla
This study identifies off-target ferrochelatase inhibition as a mechanism of vemurafenib-induced nephrotoxicity in renal tubular epithelial cells.
bioRxiv · Jan 29, 2021 · PreprintPharmacology & Toxicology
SOX9 promotes stress-responsive transcription of VGF nerve growth factor inducible gene in kidney epithelial cells
J. Y. Kim, Y. Bai, L. A. Jayne, F. Abdulkader, M. Gandhi, S. V. Parikh, M.-A. Song, A. Bajwa, N. S. Pabla
The paper identifies VGF as a stress-responsive protective gene in kidney epithelial cells, showing that SOX9 drives its transcription during injury.
bioRxiv · Jul 6, 2020Cell Biology