Author

H. W. Ong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

A. D. Axtman· 2 shared J. L. Smith· 2 shared A. N. Bullock· 1 shared C. I. Wells· 1 shared D. Drewry· 1 shared E. Chang· 1 shared E. R. Lowry· 1 shared H. Wichterle· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersPharmacology & Toxicology

A. D. Axtman

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2 papers

Recent·Most cited

Optimization of 3-Cyano-7-cyclopropylamino-pyrazolopyrimidines Toward the Development of an In Vivo Chemical Probe for CSNK2

X. Yang, H. W. Ong, R. J. Dickmander, J. L. Smith, J. W. Brown, W. Tao, E. Chang, N. J. Moorman, A. D. Axtman, T. M. Willson

The paper develops analogs of SGC-CK2-1 to improve pharmacokinetic properties in mice by inhibiting GST and P450 enzymes through co-dosing protocols.

bioRxiv · May 15, 2023Pharmacology & Toxicology

A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective

H. W. Ong, Y. Liang, W. Richardson, E. R. Lowry, C. I. Wells, X. Chen, M. Silvestre, K. Dempster, J. A. Silvaroli, J. L. Smith, H. Wichterle, N. S. Pabla, S. K. Ultanir, A. N. Bullock, D. Drewry, A. D. Axtman

The paper develops a potent and selective CDKL5/GSK3 chemical probe and demonstrates its neuroprotective effects in human motor neurons under ER stress.

bioRxiv · Feb 9, 2023 · PreprintCell Biology