R. Sah

LRRC8A anion channels modulate vasodilation via association with Myosin Phosphatase Rho Interacting Protein (MPRIP)

This study shows LRRC8A anion channels interact with MPRIP to regulate vascular relaxation and inflammation through redox-dependent cytoskeletal changes.

Socio-demographic determinants of monkeypox virus preventive behavior: a cross-sectional study in Pakistan

This study assesses knowledge, attitudes, and practices of monkeypox virus in Pakistan, finding that gender, education, and income influence preventive behaviors.

Small molecule SWELL1-LRRC8 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes

This study identifies small molecule modulators of the SWELL1-LRRC8 complex that improve glycemic control and prevent NAFLD in murine T2D by restoring insulin signaling and secretion.

Syrbactin-class dual constitutive- and immuno-proteasome inhibitor TIR-199 impedes myeloma-mediated bone degeneration in vivo.

This study characterizes TIR-199, a proteasome inhibitor that effectively targets myeloma and shows in vivo activity against bone degeneration.

Resident Cardiac Macrophages Mediate Adaptive Myocardial Remodeling

This study identifies CCR2- resident cardiac macrophages as critical for adaptive myocardial remodeling in heart failure, showing their role in ventricular remodeling and coronary angiogenesis.

The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS-mTOR signaling and vascular function

This study shows that SWELL1 regulates endothelial AKT-eNOS and mTOR signaling, affecting vascular function and contributing to hypertension and vascular narrowing in Type 2 diabetes.

SWELL1-LRRC8 complex regulates skeletal muscle cell size, intracellular signalling, adiposity and glucose metabolism

This study identifies the SWELL1-LRRC8 complex as a mechanosensor regulating skeletal muscle size, signaling, adiposity, and glucose metabolism through PI3K-AKT-mTOR pathways.

SWELL1 is a glucose sensor required for β-cell excitability and insulin secretion

This study identifies SWELL1 as a glucose sensor in β-cells that links glucose-induced swelling to chloride current activation, which is required for glucose-stimulated insulin secretion.