A. Peck

Structural basis for functional properties of cytochrome c oxidase

This study reveals the structural differences between the oxidized O state and the metastable OH state of cytochrome c oxidase using spectroscopy and crystallography, showing how Y244's protonation state affects proton translocation.

Automatic Abdominal Multi Organ Segmentationusing Residual UNet

This paper develops a residual UNet model for abdominal multi-organ segmentation using CT and MRI scans, achieving high Dice scores in held-out tests.

Skopi: a simulation package for diffractive imaging of noncrystalline biomolecules

Skopi generates diffraction images for various XFEL experiments to aid in developing feedback mechanisms for non-crystalline biomolecular structure analysis.

Montage electron tomography of vitrified specimens

The paper introduces a montage electron tomography method to improve field of view while maintaining resolution in cryo-EM, demonstrating its effectiveness on HeLa cells.

Inhibition of SARS-CoV-2 main protease by allosteric drug-binding

The paper identifies 37 compounds binding to SARS-CoV-2 main protease through X-ray crystallography, with five non-peptidic compounds showing antiviral activity in cell-based assays.

Challenges in solving structures from radiation-damaged tomograms of protein nanocrystals assessed by simulation

This paper evaluates a data processing pipeline for solving protein structures from radiation-damaged tomograms of nanocrystals using simulations.

Catalytic cleavage of HEAT and subsequent covalent binding of the tetralone moiety by the SARS-CoV-2 main protease

The paper presents the crystal structure of SARS-CoV-2 main protease covalently bound to a metabolite of HEAT, revealing a pro-drug mechanism and potential for non-peptidic inhibitors.