K. Ogata

Highly Sequence-specific, Timing-controllable m6A Demethylation by Modulating RNA-binding Affinity of m6A Erasers

This study develops a timing-controllable m6A demethylation tool with reduced off-target effects by combining PUF RNA-binding proteins with m6A-erasers and a rapamycin-based switch.

Structure of the human Bre1 complex bound to the nucleosome

The paper determines the cryo-EM structure of the human Bre1 complex bound to the nucleosome, revealing how it catalyzes H2B monoubiquitination and its potential role in cancer.

Protein N-Terminomics Reveals Major Proteases in Regulating Beige Adipocyte Differentiation

This study identifies proteases regulating beige adipocyte differentiation through N-terminomics and functional experiments.

IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay

This study identifies a novel interaction between Regnase-1 and 14-3-3 mediated by IRAK1 that stabilizes inflammatory mRNAs by inhibiting Regnase-1 activity.

Structural basis of the regulation of normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD2

This study determines the cryo-EM structure of NSD2 bound to a nucleosome and identifies oncogenic mutations that increase its catalytic activity by altering the autoinhibitory loop conformation.

Effect of Phosphorylation on the Collision Cross Sections of Peptide Ions in Ion Mobility Spectrometry

This study systematically characterizes how phosphorylation affects collision cross sections of peptides in ion mobility spectrometry, finding that phosphorylation can reduce CCS despite increasing mass.