Author

Haddas Saad

Tel Aviv University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Gerardo Zelmar LederkremeriD· 4 shared Chaitanya PateliD· 2 shared Marina Shenkman· 2 shared Navit Ogen‐ShterniD· 2 shared Bella Groisman· 1 shared Edward AvezoviD· 1 shared Gianluca PetrisiD· 1 shared Isam KhalailaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersCell Biology

Gerardo Zelmar LederkremerORCID

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4 papers

Recent·Most cited

Mannosidases IA, IB and IC are in segregated vesicular structures and involved in both glycoprotein quality control and maturation

Haddas Saad, Marina Shenkman, Edward Avezov, Isam Khalaila, Gerardo Zelmar Lederkremer

This study identifies that ManIA, ManIB, and ManIC localize to quality control vesicles and have distinct roles in glycoprotein maturation and ERAD, with different substrate preferences.

bioRxiv · Oct 22, 2026 · PreprintCell Biology

ER-associated protein degradation initiates by retrotranslocation from the ER quality control compartment

Chaitanya Patel, Navit Ogen‐Shtern, Haddas Saad, Óscar R. Burrone, Gianluca Petris, Gerardo Zelmar Lederkremer

The paper detects early ERAD initiation events using a BAP-BirA system and shows substrates engage retrotranslocation machinery while remaining membrane-associated.

bioRxiv · Feb 6, 2026 · PreprintCell Biology

Helical charge distribution at the transmembrane-luminal interface determines subcellular localization

Haddas Saad, Ron Benyair, Tal Mazor, Gerardo Zelmar Lederkremer

The paper identifies a conserved helical charge pattern in the luminal juxtamembrane region of Class I mannosidases that determines their subcellular localization between quality control vesicles and the Golgi.

bioRxiv · Nov 12, 2025 · PreprintCell Biology

Oligosaccharyltransferase is involved in targeting to ER-associated degradation

Marina Shenkman, Navit Ogen‐Shtern, Chaitanya Patel, Haddas Saad, Bella Groisman, Metsada Pasmanik, Sonya M. Schermann, Roman Körner, Gerardo Zelmar Lederkremer

The paper identifies oligosaccharyltransferase (OST) subunits as key interactors in ER-associated degradation (ERAD), suggesting a role in late stages of quality control beyond N-glycosylation.

Cells · Oct 14, 2025Peer-reviewedCell Biology