Roman Körner

Virus-mediated tau aggregate seeding in a cellular model

This study shows that tau aggregates can be packaged into lentiviral particles and induce tau aggregation in recipient cells, suggesting a potential mechanism linking viral infections to neurodegenerative diseases.

Oligosaccharyltransferase is involved in targeting to ER-associated degradation

The paper identifies oligosaccharyltransferase (OST) subunits as key interactors in ER-associated degradation (ERAD), suggesting a role in late stages of quality control beyond N-glycosylation.

Mitochondrial proteostatic stress disrupts mitoribosome biogenesis and translation

This study shows that proteostatic stress in mitochondria impairs mitoribosome biogenesis and translation, leading to respiratory deficiency and mitochondrial DNA loss.