Gerardo Zelmar Lederkremer

Mannosidases IA, IB and IC are in segregated vesicular structures and involved in both glycoprotein quality control and maturation

This study identifies that ManIA, ManIB, and ManIC localize to quality control vesicles and have distinct roles in glycoprotein maturation and ERAD, with different substrate preferences.

ER-associated protein degradation initiates by retrotranslocation from the ER quality control compartment

The paper detects early ERAD initiation events using a BAP-BirA system and shows substrates engage retrotranslocation machinery while remaining membrane-associated.

Helical charge distribution at the transmembrane-luminal interface determines subcellular localization

The paper identifies a conserved helical charge pattern in the luminal juxtamembrane region of Class I mannosidases that determines their subcellular localization between quality control vesicles and the Golgi.

Oligosaccharyltransferase is involved in targeting to ER-associated degradation

The paper identifies oligosaccharyltransferase (OST) subunits as key interactors in ER-associated degradation (ERAD), suggesting a role in late stages of quality control beyond N-glycosylation.

Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates

This study identifies IGF2 as a disease modifier that reduces intracellular protein aggregates by promoting their extracellular disposal in Huntington's disease models.