Localized heme sensing through a ternary molecular glue
Michael Heider, Clara Hipp, Zhi Yang, Han Xiao, Tobias Beschauner, Eddie Wehri, Wencke Walter, Rumi Sherriff, Srividya Chandrasekhar, Torsten Haferlach, Julia Schaletzky, Michael Rapé
The paper shows cells use a ternary molecular glue to sense heme, triggering BACH1 degradation and HMOX1 expression to detoxify cytoplasmic heme while sparing mitochondrial heme, revealing a therapeutic vulnerability in AML.
bioRxiv · May 8, 2026 · PreprintBiochemistry