Author

Michael Heider

University of California, BerkeleyORCID 0000-0001-6218-8828Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Michael RapéiD· 2 shared Tobias Beschauner· 2 shared Alex ZelteriD· 1 shared Clara HippiD· 1 shared Diane L. HaakonseniD· 1 shared Eddie WehriiD· 1 shared Han Xiao· 1 shared Julia SchaletzkyiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

Michael RapéORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintMay 8, 2026

Localized heme sensing through a ternary molecular glue

Michael Heider, Clara Hipp, Zhi Yang…·Michael Rapé

The paper shows cells use a ternary molecular glue to sense heme, triggering BACH1 degradation and HMOX1 expression to detoxify cytoplasmic heme while sparing mitochondrial heme, revealing a therapeutic vulnerability in AML.

2 citations

humanexperimental assay

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BiochemistryNaturePeer-reviewedMay 6, 2025

The molecular basis of integrated stress response silencing

Zhi Yang, Diane L. Haakonsen, Michael Heider…·Michael Rapé

This study determines the structure of the human E3 ligase SIFI, revealing its mechanism for ubiquitinating multiple substrates to silence the integrated stress response.

30 citationstop 1%

humanexperimental assay

𝕏 PostBluesky