Clara Hipp

The paper shows cells use a ternary molecular glue to sense heme, triggering BACH1 degradation and HMOX1 expression to detoxify cytoplasmic heme while sparing mitochondrial heme, revealing a therapeutic vulnerability in AML.

This study identifies QKI as a regulator of splicing fidelity during cardiogenesis by interacting with U6 snRNA to enhance splicing at weak 5' splice sites.