Sarah L. Svensson

Human-targeted drugs impact antibiotic sensitivity and growth of Campylobacter jejuni

This study shows that human-targeted drugs can both enhance antibiotic resistance and inhibit Campylobacter jejuni growth through efflux pump activation and direct toxicity.

A transcriptome map reveals conserved and lineage-specific sRNAs that regulate motility and metabolism across Vibrio

The paper maps sRNAs in Vibrio parahaemolyticus, identifies conserved and lineage-specific sRNAs, and shows their roles in regulating motility and metabolism.

Wave succession in the pandemic clone of Vibrio parahaemolyticus driven by gene loss

The paper investigates gene loss in Vibrio parahaemolyticus pandemic clones, showing it drives wave succession through environmental and transmission advantages.

Molecular model of a bacterial flagellar motor in situ reveals a "parts-list" of protein adaptations to increase torque

The paper determines the in situ structure of a high-torque bacterial flagellar motor using cryogenic electron microscopy, revealing protein adaptations and universal principles of torque generation.

Functional coherence of bacterial ecospecies

The paper experimentally links a multilocus ecospecies genotype in Vibrio parahaemolyticus to a swimming phenotype in viscous environments, showing functional coherence of ecospecies.

A small protein essential for flagellar assembly and virulence of Campylobacter jejuni

This study identifies a small protein, PflE, essential for flagellar assembly and virulence in Campylobacter jejuni by using transposon sequencing in a humanized tissue model.

A putative bacterial ecocline in Klebsiella pneumoniae

The paper identifies a genetic ecocline in Klebsiella pneumoniae using PCA, suggesting diversifying selection on a quantitative trait, with Kpa fimbriae as a potential candidate.

RNA interactome of hypervirulent Klebsiella pneumoniae reveals a small RNA inhibitor of capsular mucoviscosity and virulence

This study identifies ArcZ as a small RNA inhibitor of capsular hypermucoviscosity and virulence in hypervirulent Klebsiella pneumoniae through RNA interactome profiling.

Complementary Ribo-seq approaches map the translatome and provide a small protein census in the foodborne pathogen Campylobacter jejuni

The paper uses complementary Ribo-seq methods to map the translatome of Campylobacter jejuni, identifying novel small open reading frames and refining gene annotations.

RiboReport - Benchmarking tools for ribosome profiling-based identification of open reading frames in bacteria

The paper benchmarks ORF prediction tools for bacterial Ribo-seq data, finding DeepRibo performs well but none detect all novel sORFs with high sensitivity.

HRIBO - High-throughput analysis of bacterial ribosome profiling data

HRIBO is a workflow for analyzing bacterial Ribo-seq data to discover novel ORFs, using annotation-independent methods and integrating additional features for prioritization.