Upon microbial challenge human neutrophils undergo rapid changes in nuclear architecture to orchestrate an immediate inflammatory gene program
Matthew Denholtz, Yina Zhu, Zhaoren He, Hanbin Lu, Takeshi Isoda, Simon Döhrmann, Victor Nizet, Cornelis Murre
This study shows that human neutrophils reposition inflammatory genes to a transcriptionally permissive compartment within hours of microbial exposure, enabling rapid transcriptional responses.
Genes & Development · Feb 1, 2020Peer-reviewedGenomics