Author

Matthew Denholtz

University of California San Diego

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:spatial domain detection· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Cornelis MurreiD· 3 shared Yina ZhuiD· 2 shared Zhaoren HeiD· 2 shared Alexandra BortnickiD· 1 shared Frank AlberiD· 1 shared Hanbin Lu· 1 shared Ke Qin GongiD· 1 shared Kenian Chen· 1 shared

Activity by Year

2017-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersGenomics

Cornelis MurreORCID

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3 papers

Recent·Most cited

Upon microbial challenge human neutrophils undergo rapid changes in nuclear architecture to orchestrate an immediate inflammatory gene program

Matthew Denholtz, Yina Zhu, Zhaoren He, Hanbin Lu, Takeshi Isoda, Simon Döhrmann, Victor Nizet, Cornelis Murre

This study shows that human neutrophils reposition inflammatory genes to a transcriptionally permissive compartment within hours of microbial exposure, enabling rapid transcriptional responses.

Genes & Development · Feb 1, 2020Peer-reviewedGenomics

An inter-chromosomal transcription hub activates the unfolded protein response in plasma cells

Alexandra Bortnick, Zhaoren He, Megan Aubrey, Vivek Chandra, Matthew Denholtz, Kenian Chen, Yin C Lin, Cornelis Murre

bioRxiv · Apr 7, 2018 · PreprintImmunology

Comprehensive characterization of neutrophil genome topology

Yina Zhu, Ke Qin Gong, Matthew Denholtz, Vivek Kumar Chandra, Mark P. Kamps, Frank Alber, Cornelis Murre

This study characterizes the genome topology of neutrophils, revealing super-contraction and chromatin reorganization during differentiation.

bioRxiv · Jan 15, 2017Molecular Biology