Balancing spatial resolution and proteome depth in LC-MS based spatialproteomics
Mandy Meijer, Jeongwoo Hong, Tobias T. Pohl, Tomáš Koudelka, Claudio Bassot, Hanna Hoernberg, Sumin Lee, Hee Sool Rho, Amos Chungwon Lee, Vicent Pelechano, Ilaria Piazza
This study evaluates the trade-off between spatial resolution and proteome depth in spatial proteomics using SLACS, showing that few-cell sampling maintains proteomic information while increasing spatial specificity.
bioRxiv · Aug 28, 2026 · PreprintBiochemistry