Tomáš Koudelka

This study evaluates the trade-off between spatial resolution and proteome depth in spatial proteomics using SLACS, showing that few-cell sampling maintains proteomic information while increasing spatial specificity.

This study shows that spreading α-synuclein alters organelle communication and disrupts neuron-astrocyte mitochondrial quality control.

This study identifies HAP40 as a proteostasis regulator that controls HTT interactions and mHTT secretion, impacting cellular homeostasis and pathobiology.

The paper develops PIA-M, a multimodal transformer-based tool for predicting HLA-II peptide presentation, achieving higher accuracy and faster runtime than existing methods.