Ilaria Piazza

This study evaluates the trade-off between spatial resolution and proteome depth in spatial proteomics using SLACS, showing that few-cell sampling maintains proteomic information while increasing spatial specificity.

This study shows that spreading α-synuclein alters organelle communication and disrupts neuron-astrocyte mitochondrial quality control.

This study identifies HAP40 as a proteostasis regulator that controls HTT interactions and mHTT secretion, impacting cellular homeostasis and pathobiology.

The paper uses pooled overexpression screens to identify PIPPI, a novel microprotein involved in the ER stress response, by screening sORFs for cytoprotective effects against 6-thioguanine.

The paper shows that ribosomes modulate transcriptome abundance through frameshifts and out-of-frame mRNA decay in yeast under poor nutritional conditions, with conservation across species.

The paper identifies metabolite-protein interactions in the Calvin cycle of cyanobacteria and lithoautotrophic bacteria, revealing species-specific regulation and feed-forward activation mechanisms.

The paper identifies mRNA stability regulation as a factor modulating transcriptional memory in yeast, showing it enhances gene expression remodelling in primed cells.

The paper identifies chromatin-sensitive cryptic promoters in yeast that generate alternative protein isoforms through truncated mRNAs.

LiP-Quant identifies drug targets in complex proteomes using limited proteolysis and mass spectrometry, providing EC50 estimates and distinguishing between homologous proteins.